Cancer Genomic Medicine: Clinical Validation and Utility
نویسنده
چکیده
Rudimentary understanding of biological significances of various genomic alterations is causing slow paced translation of cancer genome sciences to personalized medicine. Comprehensive databases of genetic variations associated to effective cancer prevention approaches, early detection and treatment responses are required to successfully utilize the large amounts of information generated by current genetic tools. Efforts towards incorporation of advanced genomic technologies into clinical practice will help bringing research driven improvements in cancer diagnosis and individualized medical care.
منابع مشابه
Genomic Biomarkers for Personalized Medicine: Development and Validation in Clinical Studies
The establishment of high-throughput technologies has brought substantial advances to our understanding of the biology of many diseases at the molecular level and increasing expectations on the development of innovative molecularly targeted treatments and molecular biomarkers or diagnostic tests in the context of clinical studies. In this review article, we position the two critical statistical...
متن کاملTowards decision-making using individualized risk estimates for personalized medicine: A systematic review of genomic classifiers of solid tumors
Recent advances in the understanding of the genetic underpinnings of cancer offer the promise to customize cancer treatments to the individual through the use of genomic classifiers (GCs). At present, routine clinical utilization of GCs is uncommon and their current scope and status, in a broad sense, are unknown. As part of a registered review (PROSPERO 2014:CRD42014013371), we systematically ...
متن کاملRole of Nanodiamonds in Drug Delivery and Stem Cell Therapy
Context: The use of nanotechnology in medicine and more specifically drug delivery is set to spread rapidly. Currently many substances are under investigation for drug delivery and more specifically for cancer therapy. Evidence Acquisition: Nanodiamonds (NDs) have contributed significantly in the development of highly efficient and successful drug delivery systems, and in stem cell therapy. Dru...
متن کاملMolecular Dimensions of Gastric Cancer: Translational and Clinical Perspectives.
Gastric cancer is a global health burden and has the highest incidence in East Asia. This disease is complex in nature because it arises from multiple interactions of genetic, local environmental, and host factors, resulting in biological heterogeneity. This genetic intricacy converges on molecular characteristics reflecting the pathophysiology, tumor biology, and clinical outcome. Therefore, u...
متن کاملUtility Estimation of Health Status of Cancer Patients by Mapping for Cost-Utility Analysis
Background: It is important to obtain accurate information about the preferences of people for measuring quality-adjusted life years (QALYs), because it is necessary for cost-utility analysis. In this regard, mapping is a method to access this information. Therefore, the purpose of this study was to map Functional Assessment of Cancer Therapy – General (FACT-G) onto Short Form Six Dimension (SF...
متن کامل